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What is Calcium Ascorbate Buffered Vit-C?

Calcium Ascorbate is a nutritional supplement and food additive, and more specifically, it is a buffered form of Vitamin C (Ascorbic Acid). As it is the calcium salt of ascorbic acid, when taken as a nutritional supplement, it is better tolerated with fewer side effects of gastrointestinal upset than unbuffered ascorbic acid. Calcium Ascorbate has Calcium reacted with ascorbic acid to buffer the acidic nature of this vitamin, making it more gentle for the special needs of those who may have a sensitive gastrointestinal tract. The pH of this buffered mineral Ascorbate is approximately 6.8—7.4 as compared to ascorbic acid that is about a pH of 2.5. As a food additive it is commonly used to sliced apples appearing fresh so they do not brown as quickly when exposed to the air. When consumed, Calcium Ascorbate is hydrolyzed in the stomach yielding calcium and ascorbate ion. The stomach acid HCl changes this ascorbate ion to ascorbic acid, and as such there is no net increase in the acid levels in the stomach.

This natural source of Vitamin C in Calcium Ascorbate is much more readily absorbed in the blood stream than the other forms of calcium. Importantly, calcium and ascorbic acid are coupled to deliver the benefits of both calcium & Vitamin C. Awareness of the need of calcium for long term bone health has grown significantly and calcium fortification can now be found almost everywhere in the food chain. While Vitamin C is the most popular supplement, its health promoting benefits go far beyond its availability. It is effective against common colds and it is also one of the best-known antioxidants or free radical scavengers. Calcium ascorbate is not just meant for athletes in training and the elderly but also for people who simply want to become healthier by strengthening their muscle and bones and to reverse or slow down the aging process. As a strong antioxidant that is very effective in neutralizing free radicals in the body, Calcium ascorbate is an immune booster that can aid in fighting bacterial infections. Aside from the known calcium benefit of promoting bone and tooth formation, Calcium ascorbate is also anti-carcinogenic, antitumorigenic, and it may even help reduce the amount of bad cholesterol in the blood and prevent prostate cancer. Aside from all the benefits already mentioned as a source of vitamin C and calcium, since calcium ascorbate is a neutral salt, its gentleness to the stomach is natural and it can help replace any calcium that vitamin c might remove from their system.

What is Calcium Ascorbate Buffered Vit-C used for and who uses it?

The gentleness of Calcium Ascorbate significantly benefits the severely ill suffering from nausea and diarrhea that require Vitamin C the most because it allows them to take sufficient vitamin C to help the healing process. More often than not such individuals are already in a downward spiral since they cannot take in the nutrients that they need to regain their health, resulting to more complications. Since Calcium Ascorbate is a neutral salt and not an acid, more people (including those with sensitive stomachs) can ingest larger amounts without acid upset or diarrhea. Equally important is that Calcium Ascorbate restores the calcium that is eliminated through the urine due to the chelating properties of Vitamin C. One way to guarantee that vitamin C does not remove more calcium than what is taken is to take vitamin C as Calcium Ascorbate. Ascorbate (vitamin C) is also reducing sugar that is crucial in many biochemical processes such as hydroxylation of proline and lysine used in the formation of collagen and healthy connective tissue. A deficiency in Ascorbate results in a disease called scurvy, and its symptoms include weakened collagen fibers, rotting teeth, delayed healing and open sores on the skin. Ascorbate is also important in many other critical functions such as the mobilization of iron, stimulation of immune system and as an anti-oxidant for scavenging of reactive free radicals.

Vitamin C has numerous benefits either as a coenzyme or cofactor. Apart from its role in collagen synthesis and has a structural role in bone, cartilage and teeth, Vitamin C is also responsible for building, maintaining, and strengthening our tissues and immune system. Vitamin C is also essential for the oxidation of phenylalanine and tyrosine, the conversion of folacin to tetrahydrofolic acid, and it is required as well for synthesis of dopamine, noradrenaline and adrenaline in the nervous system or in the adrenal glands. Carnitine, a nutrient necessary in the transfer of energy to the cell mitochondria, also requires Vitamin C to complete its function. As an antioxidant, Vitamin C neutralizes harmful reactions in the watery parts of the body (for example blood and the fluid inside and surrounding cells) and some of the damage caused by free radicals, harmful by-products formed when food is converted into energy. Vitamin C may help reduce bad or LDL cholesterol and triglycerides, while increasing HDL levels. Vitamin C's antioxidant activity may be beneficial in preventing some cancers and heart disease. By relaxing the arteries and reducing the tendency of platelets to clump together, Vitamin C may shield against cardiovascular disease. As a powerful antioxidant, vitamin C may help fight or keep cancer at bay by protecting healthy cells from free-radical damage and limiting the proliferation of cancerous cells. The antioxidant properties of vitamin C are also believed to protect smokers, as well as people exposed to secondhand smoke, from the harmful effects of free radicals. In essence, Vitamin C strengthens the collagen structure of arteries, lowers total cholesterol, and blood pressure, and inhibits platelet aggregation.

How pure is your Calcium Ascorbate Buffered Vit-C?

This Purebulk Calcium Ascorbate Buffered Vit-C is assayed by the manufacturer to be 99.7% pure. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder product. The total CLA composition of this pure bulk liquid oil product is 81.06% by weight with the remaining non-CLA products being other food grade vegetable oils as assayed in the attached COA (Certificate of Analysis). Many plants and animals do not need to consume foods high in ascorbic acid to meet their need for Vitamin C because they are genetically predisposed to synthesize enzymes that convert glucose into ascorbic acid. Since ascorbic acid is a relatively fragile molecule and is easily destroyed by oxidation, particularly in the presence of heat and alkalinity, and since humans have only 3 of the 4 enzymes necessary for internal production of ascorbic acid, we must satisfy our physical needs for this important vitamin through our intake of foods rich in vitamin C and/or take a good supplement. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product also has no additives, fillers or extenders included. For individuals who want the most Calcium Ascorbate Buffered Vit-C for their money, this pure bulk product is one of the most potent and economical Calcium Ascorbate Buffered Vit-C supplement available. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of Calcium Ascorbate Buffered Vit-C?

The recommended dietary allowance (RDA) ascorbic acid in nonsmokers is 75 mg per day for women and 90 mg per day for men. For smokers, the suggested daily amounts are 110 mg per day for women and 125 mg per day for men. To maximize plasma and lymphocyte levels, typically a daily dose of 200 milligrams should be enough. You can see the full bulk density/volumetric conversion chart for Calcium Ascorbate here. Higher vitamin C intakes are needed to keep normal plasma levels under acute emotional or environmental stress such as trauma, fever, infection, or elevated environmental temperatures. Daily intakes of 200-500mg per day (in 2-3 divided doses) can lead to full blood and tissue saturation.

What kind of results do people anticipate while taking Calcium Ascorbate Buffered Vit-C?

Calcium Ascorbate is an effective dietary supplement that couples Ascorbic Acid (Vitamin C) with Calcium Carbonate. By combining these two, a buffered Vitamin C source can be used by people with sensitive stomachs or for anyone in general to ensure gastric irritation will not be experienced. As a form of vitamin C with a neutral pH, Calcium ascorbate is more bioavailable which makes it easier for your body to absorb and use, and Calcium Ascorbate Buffered Vit-C also mixes easily with food and drink. Also, since it is not as acidic as other forms of vitamin C, your body can keep it longer allowing for all the benefits of this powerful antioxidant to be used.

By combining calcium with ascorbic acid in Calcium Ascorbate Buffered Vit-C, two other benefits are achieved: the ascorbic acid facilitates calcium absorption thus making it more bioavailable to the cells, while at the same time the calcium clings onto the vitamin C, allowing the ascorbic acid to stay in the cells longer. Vitamin C (ascorbic acid) is also an antioxidant which may strengthen the immune system. It is of paramount importance for the growth and repair of tissues, the formation of collagen, the healing of wounds, and may also shield blood vessels. Vitamin C may also enhance the absorption of iron, when taken at the same time.

Precautions and Potential side effects of Calcium Ascorbate Buffered Vit-C

While vitamin C is generally non-toxic, in high doses in excess of 2,000 mg daily it can result to gastrointestinal side effects such as diarrhea, gas, or stomach upset, as well as nausea, and the risk of developing kidney stones might increase as well. If any of these effects persist or worsen, notify your doctor promptly. Large intakes of vitamin C from Calcium Ascorbate Buffered Vit-C or any other source can deplete the body of copper, an essential nutrient. Since Vitamin C enhances iron absorption, people with iron overload conditions (hemochromatosis etc.) should avoid this. As for those who have kidney problems, before taking vitamin C supplements or any supplement for that matter it is always best to consult your healthcare provider just to be on the safe side. Also inform your doctor of your medical history, especially of conditions and diseases such as diabetes, blood disorders, kidney stones, high calcium level (hypercalcemia), parathyroid disease, any drug or food allergies. For expectant mothers, ascorbic acid is considered safe during pregnancy when taken in proper doses. Although there have been no reports of harm to nursing infants, since ascorbic acid passes into breast milk, consult your doctor before breast-feeding.

Solubility and Suggested preparation of Calcium Ascorbate Buffered Vit-C

Vitamin C is water soluble and is regularly excreted by the body. Ascorbate calcium is the calcium salt form of ascorbic acid (also known as vitamin C) that is used to prevent and treat scurvy, a vitamin C deficiency. Vitamin C may also be used in persons with chronic illness, burns, certain blood disorders, or as dietary supplement. Take this medication by mouth, usually once daily; or take as directed by your doctor. It may be taken without regard to food. Take this supplement with a full 8 oz/240 ml glass of water, and do not lie down for about half an hour after taking this. Mix the powder form in a glass of juice or water. Stir well and drink the mixture immediately.

Calcium Ascorbate Buffered Vit-C is used in the following Proprietary Formulas

NOW Calcium Ascorbate Powder, NutriBiotic Calcium Ascorbate, Life Extension Calcium Ascorbate Powder, Natural Factors C Calcium Ascorbate Powder, Country Life's Calcium Ascorbate Crystals Powder, Solgar Calcium Ascorbate Crystals

References and Further Research

Intestinal absorption of calcium from calcium ascorbate in rats
The intestinal absorption of calcium (Ca) from Ca ascorbate (Ca-AsA) was investigated in normal rats. These results indicate that the absorbability of Ca from Ca-AsA is almost comparable with, or higher than, that from CaCl2 and significantly higher than that from CaCO3 because of its high degree of solubility in the intestine. Therefore, Ca-AsA would be useful as a Ca supplement with relatively high absorption from intestine.

Safety of High-level Vitamin C Ingestion
An attempt has been made in this review to select papers that represent opposing views and to present a critical nonbiased interpretation of the results. This has led to the conclusion that the practice of ingesting large quantities of ascorbic acid will not result in calcium-oxalate stones, increased uric acid excretion, impaired vitamin B12 status, iron overload, systemic conditioning, or increased mutagenic activity in healthy individuals.

Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and alpha-Tocopherol (Vitamin E)
The premise that oxidative stress, among several other factors, plays an important role in atherogenesis implies that the development and progression of atherosclerosis can be inhibited by antioxidants. In this minireview we discuss several mechanisms by which the antioxidants ascorbate (vitamin C) and alpha -tocopherol (vitamin E) may protect against atherosclerosis. These mechanisms include inhibition of LDL oxidation and inhibition of leukocyte adhesion to the endothelium and vascular endothelial dysfunction. Overall, ascorbate appears to be more effective than alpha-tocopherol in mitigating these pathophysiological processes, most likely as a result of its abilities to effectively scavenge a wide range of reactive oxygen and nitrogen species and to regenerate alpha -tocopherol, and possibly tetrahydrobiopterin, from its radical species. In contrast, alpha -tocopherol can act either as an antioxidant or a pro-oxidant to inhibit or facilitate, respectively, lipid peroxidation in LDL. However, this pro-oxidant activity of alpha -tocopherol is prevented by ascorbate acting as a coantioxidant. Therefore, an optimum vitamin C intake or body status may help protect against atherosclerosis and its clinical sequelae, whereas vitamin E may only be effective in combination with vitamin C.

Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial
There is a large body of evidence that reactive oxygen species (ROS) produced during myocardial ischemia and reperfusion play a crucial role in myocardial damage and endothelial dysfunction. The MIVIT pilot trial was designed to test the effects of antioxidant ascorbic acid and vitamin E on the clinical outcome of patients with AMI. In this randomized, double-blind, multicenter trial, 800 patients (mean age 62) with AMI were randomly allocated to receive, on top of routine medication, one of two treatments: ascorbic acid (1000 mg/12 h infusion) followed by 1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30 days. Primary end point (composite of in-hospital cardiac mortality, non-fatal new myocardial infarction, VT/VF/ asystole, shock / pulmonary edema) occurred less frequently in patients treated with antioxidants. This randomized pilot trial shows that supplementation with antioxidant vitamins ascorbic acid and vitamin E is safe and seems to positively influence the clinical outcome of patients with AMI.

Ascorbic acid supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial
Ascorbic acid is involved in the synthesis and degradation of collagen and is important for maintenance of the chorioamniotic membranes. Inadequate availability of ascorbic acid during pregnancy has been proposed as a risk factor for premature rupture of the chorioamniotic membranes (PROM). The objective of the study was to evaluate the effectiveness of 100 mg ascorbic acid per day in preventing PROM. A controlled double-blind trial was performed. Pregnant women (n = 126) in their 20th wk of gestation were invited; 120 accepted and were randomly assigned to 2 groups (100 mg ascorbic acid or placebo). Every 4 wk, plasma and leukocyte ascorbic acid concentrations were measured, and each subject was evaluated for cervicovaginal infection. The incidence of PROM was recorded for each group as an indicator of the protective effect of ascorbic acid supplementation. One hundred nine patients finished the study. Mean plasma ascorbic acid concentrations decreased significantly throughout the pregnancy in both groups, and there were no significant differences between groups. Between weeks 20 and 36, mean leukocyte ascorbic acid concentrations decreased from 17.5 to 15.23 microg/10(8) cells in the placebo group and increased from 17.26 to 22.17 microg/10(8) cells in the supplemented group (within- and between-group differences. The incidence of PROM was 14 per 57 pregnancies (24%) in the placebo group and 4 per 52 pregnancies (7%) in the supplemented group. Daily supplementation with 100 mg vitamin C after 20 wk of gestation effectively lessens the incidence of PROM. l ascorbic acid

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